hrp0094p2-7 | Adrenals and HPA Axis | ESPE2021

Emotion regulation in congenital adrenal hyperplasia

van’t Westeinde Annelies , Zimmermann Marius , Savic Ivanka , Lajic Svetlana ,

Objective: Oral hydrocortisone medication for Congenital Adrenal Hyperplasia (CAH) could lead to suboptimal blood cortisol levels throughout the day. In addition, the HPA-axis is rendered inflexible in patients. Cortisol is crucially involved in the stress response as well as in generating and regulating emotional responses to stimuli. Sub-optimal cortisol levels, in combination with a less flexible HPA-axis, could therefore lead to problems with emotion regul...